久久精品中文闷骚内射I亚洲最新在线观看Iaaa级片I91精品国产乱码久久久I欧美日韩爱爱视频I九色视频在线观看I日韩一级影片I久久精品夜色噜噜亚洲a∨I黄色的网站在线I久久亚洲av午夜福利精品一区I国产精品久久久久久久久久久久午I国产精品日韩在线观看I亚洲图片二区I成年人网站在线观看视频I欧美激情二区三区Iav在线地址I国产做爰高潮呻吟视频I国产ts变态重口人妖hdI第一色综合I69日本xxxxxxxx96I激情久久一区I综合国产精品I欧美精品色图I毛茸茸毛片I中文字幕人妻无码系列第三区Iwww.夜色

一.產品名稱：Recombinant Human sRANK Ligand

二.Catalog Number:310-01

三.Synonyms:

soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor)

四.Description:

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant human sRANKL is a 20.0 kDa polypeptide comprising the TNF homologous region of RANKL (176 amino acid residues).

五.AA Sequence:

MEKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

Determined by its ability to induce NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected ED₅₀ for this effect is 10.0-25.0 ng/ml.

九.Cross Reactivity:Mouse, Rat, Human

十.www.peprotech.com